Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 7/20 | 0.48 |
| ▸ | RORC | P51449 | 4/20 | 0.45 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.42 |
| ▸ | SPPL2A | Q8TCT8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2585419 | 0.92 | RORC (0.46) | BACE1RORCTAS2R14CNR2ADAMTS5 | |
| SCHEMBL6473313 | 0.91 | SPPL2A (0.50) | BACE1RORCTAS2R14MEN1KMT2A | |
| SCHEMBL2581195 | 0.82 | TAS2R14 (0.51) | BACE1RORCTAS2R14CNR2PSEN1 | |
| SCHEMBL2577597 | 0.81 | TAS2R14 (0.50) | RORCTAS2R14PSEN1PSEN2APH1B | |
| SCHEMBL15157850 | 0.80 | TAS2R14 (0.49) | RORCTAS2R14CNR2PSEN1PSEN2 | |
| SCHEMBL8021812 | 0.80 | SPPL2A (0.50) | BACE1RORCTAS2R14CNR1PSEN1 | |
| SCHEMBL3575750 | 0.80 | TAS2R14 (0.49) | RORCTAS2R14KMT2ACNR1CNR2 | |
| SCHEMBL2579683 | 0.80 | SPPL2A (0.50) | BACE1RORCTAS2R14CNR1PSEN1 | |
| SCHEMBL2582228 | 0.79 | MMP3 (0.53) | RORCTAS2R14CNR2PSEN1PSEN2 | |
| SCHEMBL2580146 | 0.78 | ADAMTS4 (0.50) | BACE1TAS2R14CXCR3ADAMTS5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0810209-B1 | Alpha - and beta-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors | SEARLE & CO (US) | 2002-06-05 | — | — | EP | claimed |