Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | PNLIP | P16233 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7557677 | 0.83 | — | — | |
| SCHEMBL5204470 | 0.78 | MEN1 (0.42) | MEN1KMT2AMAPTPOLBTSHR | |
| SCHEMBL5204374 | 0.78 | SCN9A (0.44) | MEN1KMT2AMAPTGRM4SCN5A | |
| SCHEMBL5204086 | 0.76 | SCN9A (0.39) | MEN1KMT2AMAPTPOLBTSHR | |
| SCHEMBL5202344 | 0.71 | SCN9A (0.47) | MEN1KMT2AMAPTPOLBTSHR | |
| SCHEMBL5204622 | 0.71 | SCN9A (0.51) | SCN5ASCN9A | |
| SCHEMBL5207711 | 0.71 | SCN9A (0.43) | MEN1KMT2AMAPTPOLBTSHR | |
| Hydrochloric Acid SCHEMBL5203439 | 0.70 | SCN9A (0.50) | SCN5ASCN9A | |
| SCHEMBL5205246 | 0.69 | SCN9A (0.45) | MEN1KMT2AMAPTALDH1A1SCN5A | |
| SCHEMBL6474359 | 0.68 | MEN1 (0.43) | MEN1KMT2AMAPTPOLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165523-A1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | Krenitsky Pharmaceuticals, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000061562-A1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC. (US) | 2000-10-19 | — | — | WO | disclosed |