Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.38 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | BCL6 | P41182 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5202344 | 0.89 | SCN9A (0.47) | MEN1KMT2ASCN9AKCNH2SCN5A | |
| SCHEMBL5204622 | 0.86 | SCN9A (0.51) | SCN9AKCNH2SCN5ATTBK1TTBK2 | |
| Hydrochloric Acid SCHEMBL5203439 | 0.85 | SCN9A (0.50) | SCN9AKCNH2SCN5ATTBK1TTBK2 | |
| SCHEMBL6474359 | 0.82 | MEN1 (0.43) | MEN1KMT2ASCN9AKCNH2SCN5A | |
| SCHEMBL5204374 | 0.82 | SCN9A (0.44) | MEN1KMT2ASCN9AKCNH2SCN5A | |
| SCHEMBL6473728 | 0.79 | MAPT (0.50) | MEN1KMT2AMAPTTSHRMAPK1 | |
| SCHEMBL7460599 | 0.78 | MEN1 (0.34) | MEN1KMT2ASCN9ASCN5AMAPT | |
| SCHEMBL5205246 | 0.78 | SCN9A (0.45) | MEN1KMT2ASCN9AKCNH2SCN5A | |
| SCHEMBL6473796 | 0.77 | MAPT (0.51) | MEN1KMT2AMAPTTSHRNPC1 | |
| SCHEMBL6474559 | 0.77 | GAA (0.43) | MEN1KMT2ASCN9ASCN5AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165523-B1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC (US) | 2007-11-07 | — | — | EP | claimed |
| US-6916820-B1 | Neurotrophic substituted pyrimidines | KRENITSKY PHARMACEUTICALS, INC. (US) | 2005-07-12 | — | — | US | claimed |
| EP-1165523-B1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC (US) | 2007-11-07 | — | — | EP | disclosed |
| US-6916820-B1 | Neurotrophic substituted pyrimidines | KRENITSKY PHARMACEUTICALS, INC. (US) | 2005-07-12 | — | — | US | disclosed |