Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 10/20 | 0.67 |
| ▸ | BCR | P11274 | 10/20 | 0.67 |
| ▸ | SRC | P12931 | 4/20 | 0.67 |
| ▸ | JAK2 | O60674 | 1/20 | 0.64 |
| ▸ | FLT3 | P36888 | 1/20 | 0.64 |
| ▸ | PRKCA | P17252 | 5/20 | 0.60 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.54 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.52 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | PRKACA | P17612 | 1/20 | 0.51 |
| ▸ | PRKACG | P22612 | 1/20 | 0.51 |
| ▸ | PRKACB | P22694 | 1/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.51 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.51 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL7469444 | 0.93 | JAK2 (0.60) | ABL1BCRSRCJAK2FLT3 | |
| SCHEMBL7467187 | 0.84 | CDK2 (0.60) | ABL1BCRSRCJAK2PRKCA | |
| SCHEMBL7467324 | 0.83 | ABL1 (0.76) | ABL1BCRSRCPRKCAPIK3CG | |
| SCHEMBL12522374 | 0.81 | JAK2 (0.60) | ABL1BCRJAK2FLT3PRKCA | |
| SCHEMBL1789 | 0.80 | ABL1 (1.00) | ABL1BCRSRCJAK2PRKCA | |
| SCHEMBL4899574 | 0.80 | ABL1 (0.76) | ABL1BCRSRCPRKCACAMK2D | |
| SCHEMBL7468539 | 0.80 | ABL1 (0.71) | ABL1BCRSRCPRKCAPIK3CG | |
| SCHEMBL7464195 | 0.80 | PIK3CG (0.83) | ABL1BCRSRCJAK2FLT3 | |
| SCHEMBL7467043 | 0.80 | ABL1 (0.67) | ABL1BCRSRCJAK2PRKCA | |
| SCHEMBL4029958 | 0.79 | ABL1 (0.72) | ABL1BCRSRCJAK2PRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | claimed |
| EP-0233461-B1 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 1996-03-20 | — | — | EP | claimed |
| US-4788195-A | TREATING ASTHMA, ALLERGIC DISEASES, INFLAMMATION AND DIABETES IN MAMMALS | AMERICAN CYANAMID COMPANY (US) | 1988-11-29 | — | — | US | claimed |