SCHEMBL7462264

SCHEMBL7462264

Fc1c(F)c(F)c(Oc2ccnc3cc(Cl)ccc23)c(F)c1F

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
NR4A2 P43354 2/20 0.49
SOS2 Q07890 1/20 0.49
MAPT P10636 3/20 0.46
ALDH1A1 P00352 1/20 0.46
GLA P06280 1/20 0.46
HPGD P15428 1/20 0.46
TSHR P16473 1/20 0.46
MAPK1 P28482 1/20 0.46
HSD17B10 Q99714 2/20 0.44
CYP1A2 P05177 1/20 0.44
GAK O14976 1/20 0.44
APP P05067 2/20 0.43
KMT2A Q03164 2/20 0.42
TDP1 Q9NUW8 2/20 0.42
CCR1 P32246 1/20 0.42
PKM P14618 1/20 0.42
ALOX15 P16050 1/20 0.42
CASP1 P29466 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7461496 0.91 LMNA (0.48) LMNASMN1; SMN2NR4A2SOS2MAPT
SCHEMBL7529202 0.85 NR4A2 (0.59) LMNASMN1; SMN2NR4A2SOS2MAPT
SCHEMBL7465513 0.85 LMNA (0.48) LMNASMN1; SMN2NR4A2SOS2MAPT
SCHEMBL7467944 0.83 LMNA (0.46) LMNASMN1; SMN2NR4A2SOS2MAPT
SCHEMBL7456971 0.81 NR4A2 (0.51) LMNASMN1; SMN2NR4A2SOS2MAPT
SCHEMBL7462623 0.80 LMNA (0.54) LMNASMN1; SMN2NR4A2SOS2MAPT
SCHEMBL7467160 0.79 LMNA (0.51) LMNASMN1; SMN2NR4A2SOS2MAPT
SCHEMBL7468141 0.79 APP (0.49) LMNASMN1; SMN2NR4A2SOS2MAPT
Hydrochloric Acid SCHEMBL27295456 0.79 NR4A2 (0.50) LMNASMN1; SMN2NR4A2SOS2MAPT
SCHEMBL7462450 0.78 TRPA1 (0.47) LMNASMN1; SMN2NR4A2SOS2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0326330-B1 Quinoline fungicides DOW AGROSCIENCES LLC (US) 2002-07-24 EP claimed
US-5145843-A For plants DOWELANCO (US) 1992-09-08 US claimed
EP-0326330-B1 Quinoline fungicides DOW AGROSCIENCES LLC (US) 2002-07-24 EP disclosed