Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | PANK3 | Q9H999 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MYC | P01106 | 1/20 | 0.33 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | WNT1 | P04628 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5868899 | 0.87 | AAK1 (0.35) | BCHEACHEPANK3ATM | |
| SCHEMBL7463263 | 0.81 | GPR139 (0.45) | RAB9AKMT2AALDH1A1GSK3B | |
| SCHEMBL7469836 | 0.81 | MAOB (0.41) | RAB9AMEN1KMT2AMAPTNPC1 | |
| SCHEMBL7455415 | 0.81 | RAF1 (0.36) | RAB9ANPC1ALDH1A1SMN1; SMN2RAF1 | |
| SCHEMBL7527939 | 0.81 | RAB9A (0.38) | RAB9AMEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL6612157 | 0.78 | ALDH1A1 (0.37) | RAB9AMEN1KMT2AMAPTNPC1 | |
| SCHEMBL7142468 | 0.77 | ALOX5AP (0.37) | RAB9AMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL6610697 | 0.76 | POLB (0.39) | RAB9AMEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL6685456 | 0.76 | CHEK1 (0.38) | RAB9AKMT2AMAPTNPC1ALDH1A1 | |
| SCHEMBL17336523 | 0.75 | MEN1 (0.43) | MEN1KMT2AMAPTNPC1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224175-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001029012-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |