Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.39 |
| ▸ | VNN1 | O95497 | 1/20 | 0.39 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7141324 | 0.87 | MEN1 (0.38) | GSK3BBRAFALDH1A1MAPTMAPK1 | |
| SCHEMBL6609458 | 0.82 | GSK3B (0.43) | GSK3BALDH1A1MAPTMAPK1MEN1 | |
| SCHEMBL7459390 | 0.80 | GSK3B (0.46) | GSK3BKMT2ARAB9AGRM5HDAC3 | |
| SCHEMBL7459196 | 0.77 | MAPK14 (0.48) | GSK3BALDH1A1RAB9AGRM5NPC1 | |
| SCHEMBL7704530 | 0.76 | DHODH (0.37) | GSK3BALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL7463263 | 0.76 | GPR139 (0.45) | GSK3BALDH1A1KMT2ARAB9AGRM5 | |
| SCHEMBL7465211 | 0.75 | GSK3B (0.40) | GSK3BALDH1A1RAB9AGRM5HDAC3 | |
| SCHEMBL7467152 | 0.75 | ERCC5 (0.50) | GSK3BALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL7065166 | 0.75 | VCP (0.45) | GSK3BRAB9AGRM5HDAC3LMNA | |
| SCHEMBL7703990 | 0.75 | GSK3B (0.41) | GSK3BMAPK1MEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224174-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001029011-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |