Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9065300 | 0.80 | LDHA (0.36) | LDHASRRTSHRLMNAMMP1 | |
| SCHEMBL3415362 | 0.76 | LDHA (0.42) | LDHASRRTSHR | |
| SCHEMBL27869946 | 0.74 | — | — | |
| SCHEMBL242500 | 0.74 | TSHR (0.47) | LDHASRRTSHRLMNAMMP1 | |
| SCHEMBL4438448 | 0.74 | LDHA (0.40) | LDHASRRTSHR | |
| SCHEMBL26939174 | 0.74 | LDHA (0.40) | LDHASRRTSHRMMP1MMP2 | |
| SCHEMBL4009823 | 0.73 | CYP19A1 (0.44) | MMP1MMP2MMP3MMP9MMP13 | |
| SCHEMBL22124620 | 0.72 | MAPT (0.45) | LDHASRR | |
| SCHEMBL5349565 | 0.72 | LDHA (0.38) | LDHASRRTSHRLMNAMMP1 | |
| SCHEMBL28363264 | 0.72 | CACNA2D1 (0.41) | LMNAMMP1MMP2MMP3MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1180029-A4 | BICYCLIC ACYL GUANIDINE SODIUM/PROTON EXCHANGE INHIBITORS AND METHOD | BRISTOL MYERS SQUIBB CO (US) | 2002-10-02 | — | — | EP | disclosed |
| EP-1180029-A1 | BICYCLIC ACYL GUANIDINE SODIUM/PROTON EXCHANGE INHIBITORS AND METHOD | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-02-20 | — | — | EP | disclosed |
| WO-2000064445-A1 | BICYCLIC ACYL GUANIDINE SODIUM/PROTON EXCHANGE INHIBITORS AND METHOD | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-11-02 | — | — | WO | disclosed |