Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KIF11 | P52732 | 2/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7422911 | 0.91 | AGTR1 (0.48) | MEN1KMT2AGAASMN1; SMN2PLA2G2A | |
| SCHEMBL7468201 | 0.91 | MEN1 (0.43) | MEN1KMT2AGAASMN1; SMN2RXFP1 | |
| SCHEMBL7472399 | 0.87 | ALDH1A1 (0.39) | MEN1KMT2AGAASMN1; SMN2PLA2G2A | |
| SCHEMBL7419765 | 0.87 | PLA2G2A (0.39) | KMT2APLA2G2ACNR2 | |
| SCHEMBL7470934 | 0.87 | PLA2G2A (0.38) | MEN1KMT2AKIF11PLA2G2ATP53 | |
| SCHEMBL7420760 | 0.87 | PLA2G2A (0.38) | KMT2APLA2G2AAGTR1AGTR2NPSR1 | |
| SCHEMBL29611861 | 0.87 | ALOX5AP (0.47) | MEN1KMT2APLA2G2ARXFP1TP53 | |
| SCHEMBL7422125 | 0.87 | AGTR1 (0.39) | MEN1KMT2APLA2G2AAGTR1AGTR2 | |
| Hydrochloric Acid SCHEMBL7418164 | 0.87 | PLA2G2A (0.38) | KMT2APLA2G2A | |
| SCHEMBL687131 | 0.87 | ALOX5AP (0.47) | MEN1KMT2APLA2G2ARXFP1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |
| WO-1996032379-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-17 | — | — | WO | disclosed |