Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 3/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7419765 | 0.92 | PLA2G2A (0.39) | PLA2G2AS1PR3KMT2ANPC1 | |
| SCHEMBL7423617 | 0.90 | PLA2G2A (0.40) | PLA2G2AKDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL7463557 | 0.87 | MEN1 (0.44) | PLA2G2AMEN1KMT2ALMNAKIF11 | |
| SCHEMBL7472399 | 0.86 | ALDH1A1 (0.39) | PLA2G2AKDM4EALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL7418164 | 0.85 | PLA2G2A (0.38) | PLA2G2AS1PR3PTGDR2KMT2ANPC1 | |
| SCHEMBL29611861 | 0.85 | ALOX5AP (0.47) | PLA2G2AKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL687131 | 0.85 | ALOX5AP (0.47) | PLA2G2AKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL7422125 | 0.85 | AGTR1 (0.39) | PLA2G2AALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL7420760 | 0.85 | PLA2G2A (0.38) | PLA2G2AS1PR3HPGDKMT2ALMNA | |
| SCHEMBL7481829 | 0.85 | MAPT (0.41) | PLA2G2AS1PR3KDM4EALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |
| CN-1187812-A | Indole derivatives as CGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO (JP) | 1998-07-15 | — | — | CN | disclosed |
| WO-1996032379-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-17 | — | — | WO | disclosed |