SCHEMBL7464118

SCHEMBL7464118

OC[C@H](O)c1c(Cl)cccc1Cl

nearest known ligand 0.50

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SLC18A3 Q16572 1/20 0.41
SIGMAR1 Q99720 1/20 0.41
ADRB2 P07550 2/20 0.36
ADRB1 P08588 2/20 0.36
AOC3 Q16853 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2A6 P11509 1/20 0.36
TSHR P16473 2/20 0.36
AKR1B1 P15121 1/20 0.35
KCNJ5 P48544 4/20 0.35
KCNJ3 P48549 4/20 0.35
CYP2D6 P10635 1/20 0.35
NFKB1 P19838 1/20 0.35
HIF1A Q16665 1/20 0.35
OPRK1 P41145 1/20 0.35
LMNA P02545 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7468788 1.00 SLC18A3 (0.41) SLC18A3SIGMAR1ADRB2ADRB1AOC3
SCHEMBL16054678 0.82 SLC18A3 (0.39) SLC18A3SIGMAR1ADRB2ADRB1AOC3
SCHEMBL3185589 0.82 SLC18A3 (0.39) SLC18A3SIGMAR1ADRB2ADRB1AOC3
SCHEMBL7154328 0.79 TAAR1 (0.41) SLC18A3SIGMAR1ADRB2ADRB1AOC3
SCHEMBL4872351 0.79 TAAR1 (0.41) SLC18A3SIGMAR1ADRB2ADRB1AOC3
SCHEMBL2422707 0.79 LMNA (0.46) SLC18A3SIGMAR1ADRB2ADRB1AOC3
Hydrochloric Acid SCHEMBL11495583 0.77 APEX1 (0.42) SLC18A3SIGMAR1ADRB2ADRB1AOC3
SCHEMBL18568085 0.76 TAS1R3 (0.39) SLC18A3SIGMAR1ADRB2ADRB1AOC3
SCHEMBL16267753 0.76 ADRB2 (0.41) SLC18A3SIGMAR1ADRB2ADRB1AOC3
SCHEMBL2423544 0.76 SLC18A3 (0.38) SLC18A3SIGMAR1ADRB2ADRB1AOC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0907635-B1 HALOGEN SUBSTITUTED CARBAMATE COMPOUNDS FROM 2-PHENYL-1,2-ETHANEDIOL SK CORP (KR) 2002-09-25 EP disclosed
US-20010034365-A1 Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol CHOI YONG MOON (US) 2001-10-25 US disclosed
US-6127412-A TREATMENT OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM, ESPECIALLY AS ANTICONVULSANTS, ANTIEPILEPTIC AND NEUROPROTECTIVE AGENTS AND CENTRALLY ACTING MUSCLE RELAXANTS SK CORPORATION (US) 2000-10-03 US disclosed
US-6103759-A COMPRISING PURE ENANTIOMERIC FORMS, AS WELL AS ENANTIOMERIC MIXTURES, OF (2-(2-CHLOROPHENYL)-2-HYDROXYETHYL)OXYCARBOXAMIDE; USEFUL FOR TRATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS SK CORPORATION (US) 2000-08-15 US disclosed
EP-0907635-A1 HALOGEN SUBSTITUTED CARBAMATE COMPOUNDS FROM 2-PHENYL-1,2-ETHANEDIOL SK Corporation (KR) 1999-04-14 EP disclosed
US-5854283-A Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol YUKONG LIMITED (KR) 1998-12-29 US disclosed
WO-1997026241-A1 HALOGEN SUBSTITUTED CARBAMATE COMPOUNDS FROM 2-PHENYL-1,2-ETHANEDIOL SK CORPORATION (KR) 1997-07-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010034365-A1 Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol DDT, GRIK2, GABRD SLC18A3 664/4885SIGMAR1 934/4885ADRB2 1524/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.