Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 10/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 9/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 9/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 9/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 9/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 9/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | USP7 | Q93009 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6978800 | 0.81 | ADRA1A (0.43) | ADRA1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL6976571 | 0.77 | ADRA1A (0.40) | ADRA1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL6977305 | 0.75 | KMT2A (0.46) | MEN1KMT2ATP53MAPTALDH1A1 | |
| SCHEMBL7464130 | 0.72 | OPRD1 (0.38) | ADRA1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL6965116 | 0.70 | ADRA1A (0.49) | ADRA1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL6979779 | 0.70 | ADRA1A (0.41) | ADRA1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL6970257 | 0.69 | OPRD1 (0.41) | LMNAALDH1A1HTTL3MBTL1 | |
| SCHEMBL6975845 | 0.69 | ADRA1A (0.42) | ADRA1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL6967490 | 0.68 | OPRD1 (0.41) | ADRA1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL6975294 | 0.68 | ADRA1A (0.47) | ADRA1AADRA2AADRA2BADRA2CADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202984-A1 | NOVEL DIPHENYL-PIPERIDINE DERIVATE | AstraZeneca UK Limited (GB) | 2002-05-08 | — | — | EP | claimed |
| WO-2001005782-A1 | NOVEL DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LIMITED (GB) | 2001-01-25 | — | — | WO | claimed |