Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL7461996 | 0.99 | SIGMAR1 (0.41) | SIGMAR1ROCK2NAMPTSMN1; SMN2MEN1 | |
| Ether SCHEMBL7461990 | 0.96 | SIGMAR1 (0.39) | SIGMAR1ROCK2NAMPTSMN1; SMN2MEN1 | |
| SCHEMBL7455413 | 0.89 | SIGMAR1 (0.42) | SIGMAR1NAMPTMEN1KMT2ALMNA | |
| SCHEMBL8892340 | 0.84 | MEN1 (0.42) | SIGMAR1ROCK2NAMPTMEN1KMT2A | |
| SCHEMBL8892459 | 0.83 | F10 (0.41) | ROCK2NAMPTMEN1KMT2ALMNA | |
| SCHEMBL7458570 | 0.82 | NAMPT (0.43) | NAMPTSMN1; SMN2MEN1CYP2C19KMT2A | |
| SCHEMBL7463621 | 0.82 | NAMPT (0.38) | ROCK2NAMPTSMN1; SMN2MEN1CYP2C19 | |
| SCHEMBL7467006 | 0.81 | ITGB3 (0.36) | SIGMAR1KMT2AF10HTR1AHTR7 | |
| SCHEMBL8892115 | 0.81 | NAMPT (0.37) | ROCK2NAMPTSMN1; SMN2MEN1CYP2C19 | |
| SCHEMBL8892614 | 0.80 | HPGD (0.43) | NAMPTSMN1; SMN2MEN1CYP2C19KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0697408-B1 | 1 substituted-phenyl-oxazolidene-2-one derivatives and their use as adhesion-receptor antagonists | MERCK PATENT GMBH (DE) | 2002-01-23 | — | — | EP | disclosed |
| US-5614535-A | Adhesion receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-03-25 | — | — | US | disclosed |
| EP-0697408-A1 | 1 substituted-phenyl-oxazolidene-2-one derivatives and their use as adhesion-receptor antagonists | MERCK PATENT GmbH (DE) | 1996-02-21 | — | — | EP | disclosed |