Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.50 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29111010 | 0.85 | ALKBH1 (0.41) | PDE5AALKBH1CLK4MEN1KMT2A | |
| SCHEMBL23767729 | 0.84 | ALKBH1 (0.51) | ALKBH1MEN1KMT2AXDHCYP3A4 | |
| SCHEMBL1163902 | 0.84 | XDH (0.45) | PDE5AALKBH1CLK4MEN1KMT2A | |
| SCHEMBL30080246 | 0.84 | ALKBH1 (0.51) | ALKBH1MEN1KMT2AXDHCYP3A4 | |
| SCHEMBL25544486 | 0.82 | ALKBH1 (0.49) | ALKBH1CLK4MEN1KMT2AXDH | |
| SCHEMBL30080394 | 0.82 | ALKBH1 (0.49) | ALKBH1MEN1KMT2AL3MBTL1XDH | |
| SCHEMBL23767730 | 0.82 | ALKBH1 (0.49) | ALKBH1MEN1KMT2AL3MBTL1XDH | |
| SCHEMBL23753904 | 0.81 | SMN1; SMN2 (0.54) | ALKBH1CLK4MEN1KMT2AMAPT | |
| SCHEMBL13763835 | 0.81 | ALDH1A1 (0.47) | CLK4MEN1KMT2AKDM4EMAPT | |
| SCHEMBL23767728 | 0.80 | ALKBH1 (0.47) | ALKBH1CLK4KDM4EL3MBTL1XDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0817773-B1 | PYRIMIDINE COMPOUNDS | QINETIQ LTD (GB) | 2002-06-12 | — | — | EP | disclosed |
| US-6121448-A | LIQUID CRYSTALLINE COMPOUNDS | THE SECRETARY OF STATE FOR DEFENCE IN HER BRITTANIC MAJESTY'S GOVERNMENT OF THE UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND (GB) | 2000-09-19 | — | — | US | disclosed |
| US-5986096-A | REACTION OF HYDROGEN IODIDE WITH CHLORO-5-BROMOPYRIMIDINE | THE SECRETARY OF STATE FOR DEFENCE IN HER BRITANNIC MAJESTY'S A GOVERNMENT OF THE U.K. OF GT. BRITAIN & N. IRELAND OF DEFENCE EVALUATION & RESEARCH AGENCY (GB) | 1999-11-16 | — | — | US | disclosed |
| WO-1996030344-A9 | PYRIMIDINE COMPOUNDS | — | 1999-02-11 | — | — | WO | disclosed |
| WO-1996030344-A2 | PYRIMIDINE COMPOUNDS | THE SECRETARY OF STATE FOR DEFENCE (GB) | 1996-10-03 | — | — | WO | disclosed |