SCHEMBL7464394

SCHEMBL7464394

Nc1cc(-c2cc(N)c(O)c(C(F)(F)F)c2)ccc1O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 5/20 0.50
ALDH1A1 P00352 5/20 0.50
ALOX15 P16050 4/20 0.50
GAA P10253 3/20 0.50
MAPT P10636 3/20 0.50
MEN1 O00255 2/20 0.50
KMT2A Q03164 2/20 0.50
HPGD P15428 2/20 0.50
ALOX12 P18054 2/20 0.50
KDM4E B2RXH2 1/20 0.50
USP2 O75604 1/20 0.50
LMNA P02545 1/20 0.50
HSP90AA1 P07900 1/20 0.50
HTT P42858 1/20 0.50
KIF11 P52732 5/20 0.44
HSD17B1 P14061 3/20 0.43
HSD17B2 P37059 3/20 0.43
CYP3A4 P08684 1/20 0.39
ERN1 O75460 2/20 0.39
AR P10275 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5667750 0.87 CA1 (0.39) ALDH1A1GAAMAPTKDM4ELMNA
SCHEMBL7718781 0.87 ALDH1A1 (0.47) HSD17B10ALDH1A1ALOX15GAAMAPT
SCHEMBL7719490 0.85 ALOX15 (0.49) HSD17B10ALDH1A1ALOX15GAAMAPT
SCHEMBL6852473 0.81 CA1 (0.36) HSD17B10ALOX15KIF11HSD17B1HSD17B2
SCHEMBL8741828 0.79 RXRA (0.36) HSD17B10ALDH1A1HPGDKDM4EKIF11
SCHEMBL5424533 0.77 ALDH1A1 (0.61) HSD17B10ALDH1A1ALOX15GAAMAPT
SCHEMBL108713 0.77 ALDH1A1 (0.77) HSD17B10ALDH1A1ALOX15GAAMAPT
SCHEMBL28822417 0.77 ALDH1A1 (0.77) HSD17B10ALDH1A1ALOX15GAAMAPT
SCHEMBL29367250 0.77 ALDH1A1 (0.77) HSD17B10ALDH1A1ALOX15GAAMAPT
SCHEMBL7455080 0.76 ALDH1A1 (0.46) HSD17B10ALDH1A1ALOX15GAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6380271-B1 MIXING A POLYBENZOXAZOLE PRECURSOR OR A POLYBENZOXAZOLE RESIN WITH AN OLIGOMER, FORMING FILM FROM RESULTING MIXTURE, HEATING FILM IN NITROGEN CONTAINING OXYGEN TO GIVE RISE TO THERMAL DECOMPOSITION AND GASIFICATION OF OLIGOMER TO FORM RESIN LAYER SUMITOMO BAKELITE COMPANY LIMITED (JP) 2002-04-30 US disclosed
EP-0990673-B1 Polybenzoxazole resin and precursor thereof SUMITOMO BAKELITE CO (JP) 2002-03-20 EP disclosed
US-6297351-B1 EXCELLENT IN ELECTRIC CHARACTERISTICS AND HEAT RESISTANCE, PRECURSOR FROM A DICARBOXYLIC ACID AND A BISAMINOPHENOL COMPOUND OR A DIAMINODIHYDROXY SUMITOMO BAKELITE COMPANY LIMITED (JP) 2001-10-02 US disclosed
US-6204356-B1 CYCLIZATION SUMITOMO BAKELITE COMPANY LIMITED (JP) 2001-03-20 US disclosed
EP-0990673-A2 Polybenzoxazole resin and precursor thereof SUMITOMO BAKELITE COMPANY LIMITED (JP) 2000-04-05 EP disclosed