Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7471569 | 0.81 | KDM4E (0.39) | MEN1KMT2ASMN1; SMN2KDM4ELMNA | |
| SCHEMBL20178499 | 0.80 | MEN1 (0.43) | MEN1KMT2ATP53CYP1A2CYP3A4 | |
| SCHEMBL18567612 | 0.78 | MEN1 (0.40) | MEN1KMT2ATP53CYP1A2CYP3A4 | |
| SCHEMBL4428343 | 0.77 | MEN1 (0.40) | MEN1KMT2ATP53CYP1A2CYP3A4 | |
| SCHEMBL7470789 | 0.76 | OPRM1 (0.48) | EPHX2OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL28058440 | 0.74 | OPRM1 (0.47) | KMT2AEPHX2OPRM1OPRD1OPRK1 | |
| SCHEMBL16951539 | 0.74 | PNMT (0.46) | MEN1KMT2ACYP1A2CYP3A4TSHR | |
| SCHEMBL24950078 | 0.73 | NR1I2 (0.39) | MEN1KMT2ATP53CYP1A2CYP3A4 | |
| SCHEMBL15351833 | 0.73 | SLC6A2 (0.44) | SMN1; SMN2KDM4EKCNH2SLC6A4SLC6A3 | |
| SCHEMBL23101932 | 0.72 | MEN1 (0.47) | MEN1KMT2ATP53CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244617-A1 | SUBSTITUTED AMINOALKYLAMIDE DERIVATIVES AS ANTAGONISTS OF FOLLICLE STIMULATING HORMONE | Ortho-McNeil Pharmaceutical, Inc. (US) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001047875-A1 | SUBSTITUTED AMINOALKYLAMIDE DERIVATIVES AS ANTAGONISTS OF FOLLICLE STIMULATING HORMONE | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-07-05 | — | — | WO | disclosed |