Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 6/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 9/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.36 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | EGFR | P00533 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7476281 | 0.91 | HRH4 (0.51) | HRH4NPC1LMNAMAPK1MAPT | |
| SCHEMBL7469030 | 0.89 | WDR5 (0.44) | HRH4NPC1LMNAMAPK1MAPT | |
| SCHEMBL7462496 | 0.88 | WDR5 (0.40) | HRH4NPC1RAB9ALMNAMAPK1 | |
| SCHEMBL7458966 | 0.87 | MAPK1 (0.47) | HRH4NPC1RAB9ALMNAMAPK1 | |
| SCHEMBL7470159 | 0.87 | HRH4 (0.41) | HRH4NPC1RAB9ALMNAMAPK1 | |
| SCHEMBL7476400 | 0.85 | MAPT (0.41) | HRH4NPC1LMNAMAPK1MAPT | |
| SCHEMBL7470693 | 0.83 | HTT (0.45) | HRH4NPC1RAB9ALMNAMAPK1 | |
| SCHEMBL7470593 | 0.83 | HTT (0.50) | HRH4MAPK1MAPTHTTMEN1 | |
| SCHEMBL7459991 | 0.82 | LMNA (0.52) | HRH4NPC1LMNAMAPK1MAPT | |
| SCHEMBL7475664 | 0.82 | EGFR (0.55) | RAB9ALMNAMAPK1MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1229025-A1 | NOVEL QUINAZOLINE DERIVATIVES | Japan Energy Corporation (JP) | 2002-08-07 | — | — | EP | disclosed |