Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 6/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | USP10 | Q14694 | 1/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.38 |
| ▸ | USP13 | Q92995 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 3/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7458966 | 0.92 | MAPK1 (0.47) | HTTMAPK1AURKAHRH4EGFR | |
| SCHEMBL7470593 | 0.91 | HTT (0.50) | HTTMAPK1HRH4PDE5ANTRK1 | |
| SCHEMBL7475282 | 0.91 | USP10 (0.48) | HTTUSP10PIK3C3USP13EGFR | |
| SCHEMBL7464890 | 0.90 | HRH4 (0.48) | HTTMAPK1HRH4PDE5ALMNA | |
| SCHEMBL7469384 | 0.88 | HTT (0.46) | HTTMAPK1USP10PIK3C3USP13 | |
| SCHEMBL7470361 | 0.86 | HTT (0.45) | HTTMAPK1USP10PIK3C3USP13 | |
| SCHEMBL7469367 | 0.85 | MAPT (0.44) | HTTMAPK1USP10PIK3C3USP13 | |
| SCHEMBL7464425 | 0.83 | HRH4 (0.41) | HTTMAPK1HRH4EGFRLMNA | |
| SCHEMBL7475664 | 0.83 | EGFR (0.55) | HTTMAPK1EGFRLMNAMAPT | |
| SCHEMBL7471389 | 0.83 | MAPT (0.41) | HTTUSP10PIK3C3USP13EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1229025-A1 | NOVEL QUINAZOLINE DERIVATIVES | Japan Energy Corporation (JP) | 2002-08-07 | — | — | EP | disclosed |