Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.50 |
| ▸ | C1R | P00736 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 4/20 | 0.46 |
| ▸ | BCHE | P06276 | 2/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.45 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7458826 | 0.90 | TP53 (0.60) | TP53ADORA2AADORA1ACHEBCHE | |
| SCHEMBL7464351 | 0.86 | ACHE (0.51) | TP53ADORA2AADORA1ACHEPDE4B | |
| SCHEMBL7464693 | 0.86 | ACHE (0.51) | TP53ADORA2AADORA1ACHEPDE4B | |
| SCHEMBL7820175 | 0.81 | TP53 (0.51) | TP53ADORA2AADORA1C1RACHE | |
| SCHEMBL7464904 | 0.80 | ESRRB (0.45) | TP53ADORA2AADORA1HTTRXFP1 | |
| SCHEMBL12285138 | 0.74 | KDM4E (0.55) | ACHEBCHESMN1; SMN2NPC1RAB9A | |
| SCHEMBL13739299 | 0.73 | KMT2A (0.61) | L3MBTL1HTTMAPTSMN1; SMN2NPC1 | |
| SCHEMBL7825423 | 0.73 | TP53 (0.51) | TP53ADORA2AADORA1PDE4BPDE4D | |
| SCHEMBL7533761 | 0.72 | KDM4E (0.54) | MAPTSMN1; SMN2NPC1MAOBRAB9A | |
| SCHEMBL7811355 | 0.72 | NTRK1 (0.50) | TP53ACHEPDE4BPDE4DKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0785191-B1 | FUSED INDAN DERIVATIVES AND SALTS THEREOF | TAIHO PHARMACEUTICAL CO LTD (JP) | 2002-10-23 | — | — | EP | disclosed |
| US-5763453-A | ANTITUMOR AGENTS | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 1998-06-09 | — | — | US | disclosed |
| EP-0785191-A1 | FUSED INDAN DERIVATIVES AND SALTS THEREOF | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 1997-07-23 | — | — | EP | disclosed |