Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRB | O95718 | 4/20 | 0.45 |
| ▸ | ESRRA | P11474 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | TOP1 | P11387 | 1/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7464639 | 0.80 | TP53 (0.60) | RAB9AMEN1KMT2APKMHTT | |
| SCHEMBL8806165 | 0.74 | TOP1 (0.40) | RAB9AMEN1KMT2APKMHTT | |
| SCHEMBL16479373 | 0.74 | ESR1 (0.43) | ESRRBESRRAMEN1KMT2AALDH1A1 | |
| SCHEMBL8573824 | 0.73 | TOP1 (0.48) | ADORA2AADORA1TOP1 | |
| SCHEMBL7458826 | 0.72 | TP53 (0.60) | RAB9AMEN1KMT2APKMHTT | |
| SCHEMBL16645288 | 0.72 | RORC (0.56) | ESRRBESRRAESR1ESR2 | |
| SCHEMBL7818757 | 0.70 | TOP1 (0.56) | RAB9AMEN1KMT2AHTTMAPT | |
| SCHEMBL7818521 | 0.69 | GUSB (0.45) | MAOBTOP1BCL2MCL1ESR1 | |
| SCHEMBL7464693 | 0.69 | ACHE (0.51) | MEN1KMT2AADORA2AADORA1TP53 | |
| SCHEMBL7464351 | 0.69 | ACHE (0.51) | MEN1KMT2AADORA2AADORA1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0785191-B1 | FUSED INDAN DERIVATIVES AND SALTS THEREOF | TAIHO PHARMACEUTICAL CO LTD (JP) | 2002-10-23 | — | — | EP | disclosed |
| US-5763453-A | ANTITUMOR AGENTS | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 1998-06-09 | — | — | US | disclosed |
| EP-0785191-A1 | FUSED INDAN DERIVATIVES AND SALTS THEREOF | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 1997-07-23 | — | — | EP | disclosed |