Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 3/20 | 0.50 |
| ▸ | ACHE | P22303 | 4/20 | 0.46 |
| ▸ | GUSB | P08236 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | ACACA | Q13085 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7822017 | 0.95 | NTRK1 (0.51) | NTRK1ACHEGUSBPDE4BPDE4D | |
| SCHEMBL3736581 | 0.90 | NTRK1 (0.51) | NTRK1ACHEGUSBPDE4BPDE4D | |
| SCHEMBL7820175 | 0.86 | TP53 (0.51) | ACHEPDE4BPDE4DTP53KDM4E | |
| SCHEMBL7825423 | 0.86 | TP53 (0.51) | PDE4BPDE4DTP53KDM4EMEN1 | |
| SCHEMBL7820788 | 0.84 | USP8 (0.42) | NTRK1ACHETP53KDM4EKMT2A | |
| SCHEMBL7464351 | 0.81 | ACHE (0.51) | NTRK1ACHEGUSBPDE4BPDE4D | |
| SCHEMBL12781496 | 0.80 | PABPC1 (0.47) | NTRK1GUSBMEN1KMT2ALMNA | |
| SCHEMBL7818521 | 0.80 | GUSB (0.45) | GUSBKDM4E | |
| SCHEMBL3738396 | 0.79 | ALOX15 (0.43) | GUSBKDM4EMEN1POLBKMT2A | |
| SCHEMBL7464693 | 0.79 | ACHE (0.51) | NTRK1ACHEGUSBPDE4BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0713870-B1 | NOVEL FUSED INDAN DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | TAIHO PHARMACEUTICAL CO LTD (JP) | 2001-07-18 | — | — | EP | disclosed |
| US-6028079-A | FOR TREATING TUMOR OF MAMMAL | TAIHO PHARMACEUTICAL CO., LTD (JP) | 2000-02-22 | — | — | US | disclosed |
| US-5733918-A | ANTITUMOR AGENT | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 1998-03-31 | — | — | US | disclosed |
| US-5710162-A | ANTITUMOR AGENTS | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 1998-01-20 | — | — | US | disclosed |
| EP-0713870-A1 | NOVEL FUSED INDAN DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 1996-05-29 | — | — | EP | disclosed |