Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 13/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 10/20 | 0.53 |
| ▸ | RPA1 | P27694 | 1/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | FABP3 | P05413 | 1/20 | 0.37 |
| ▸ | FABP4 | P15090 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8068429 | 0.84 | PTGS2 (0.52) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL7460386 | 0.81 | PTGS2 (0.64) | PTGS2PTGS1HIF1ACYP1A2CYP3A4 | |
| SCHEMBL8989537 | 0.81 | PTGS2 (0.67) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL7462538 | 0.80 | PTGS2 (0.59) | PTGS2PTGS1RPA1ABCB11ALDH1A1 | |
| SCHEMBL8690962 | 0.79 | PTGS2 (0.67) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL8925551 | 0.79 | PTGS2 (0.67) | PTGS2PTGS1ABCB11ALDH1A1HIF1A | |
| SCHEMBL7463985 | 0.79 | PTGS2 (0.67) | PTGS2PTGS1ABCB11ALDH1A1HIF1A | |
| SCHEMBL14504331 | 0.73 | PTGS2 (0.69) | PTGS2PTGS1RPA1ABCB11ALDH1A1 | |
| SCHEMBL8290876 | 0.73 | PTGS2 (0.73) | PTGS2PTGS1ABCB11ALDH1A1HIF1A | |
| SCHEMBL6209346 | 0.72 | PTGS2 (0.58) | PTGS2PTGS1RPA1ABCB11ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0554829-B1 | Pyrazole derivatives with antiinflammatory, analgesic and antithrombolic activity | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-05-15 | — | — | EP | disclosed |
| US-5670533-A | ANTIINFLAMMATORY AGENTS, ANALGESICS OR ANTIRHEUMATIC DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-23 | — | — | US | disclosed |
| US-5550147-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTITHROMBOTIC AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-08-27 | — | — | US | disclosed |
| EP-0554829-A2 | Pyrazole derivatives with antiinflammatory, analgesic and antithrombolic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-08-11 | — | — | EP | disclosed |