Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7460709 | 0.85 | MCHR1 (0.55) | MCHR1BCHEKCNA3CYP3A4CYP2D6 | |
| SCHEMBL7460619 | 0.84 | MCHR1 (0.47) | MCHR1BCHEADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL7454984 | 0.83 | MCHR1 (0.55) | MCHR1BCHEKCNA3CYP3A4CYP2D6 | |
| SCHEMBL7461210 | 0.81 | HTR7 (0.50) | MCHR1BCHEDRD2KMT2AHTR7 | |
| SCHEMBL7461976 | 0.80 | BCHE (0.55) | MCHR1BCHEKCNA3SIGMAR1DRD2 | |
| SCHEMBL7470213 | 0.78 | HTR1A (0.57) | MCHR1BCHEADRA1DADRA1AADRA1B | |
| SCHEMBL7461241 | 0.78 | OPRM1 (0.55) | MCHR1BCHEADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL7466552 | 0.77 | HTR1A (0.56) | MCHR1BCHEADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL7465301 | 0.77 | OPRM1 (0.54) | MCHR1BCHEADRA1DADRA1AADRA1B | |
| SCHEMBL7463216 | 0.75 | MCHR1 (0.60) | MCHR1KCNA3CYP3A4CYP2D6SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1219294-A1 | MELANIN CONCENTRATING HORMONE ANTAGONISTS | Takeda Chemical Industries, Ltd. (JP) | 2002-07-03 | — | — | EP | disclosed |
| EP-0712845-B1 | Amine compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-10-17 | — | — | EP | disclosed |
| US-5633248-A | GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS, DIARYLALKYLIDENEDIAMINES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-05-27 | — | — | US | disclosed |
| EP-0712845-A1 | Amine compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-05-22 | — | — | EP | disclosed |