Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGER | Q15109 | 1/20 | 0.59 |
| ▸ | SRC | P12931 | 3/20 | 0.49 |
| ▸ | YES1 | P07947 | 1/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | BCR | P11274 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | PRKCA | P17252 | 1/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.46 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 4/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7466120 | 0.84 | AGER (0.67) | AGERSRCYES1PIK3CGPIK3CA | |
| SCHEMBL7464616 | 0.82 | ABL1 (0.68) | AGERSRCPIK3CGPIK3CAPIK3CB | |
| SCHEMBL13924608 | 0.81 | SYK (0.66) | AGERSRCYES1FGFR1FGFR3 | |
| SCHEMBL7052367 | 0.81 | AGER (0.66) | AGERSRCYES1PIK3CGPIK3CA | |
| SCHEMBL7052995 | 0.81 | AGER (0.60) | AGERSRCYES1PIK3CGPIK3CA | |
| SCHEMBL7464926 | 0.78 | AIMP2 (0.58) | SRCABL1BCREGFRPRKCA | |
| SCHEMBL7471212 | 0.77 | CDK5 (0.47) | SRCPIK3CGPIK3CAPIK3CBABL1 | |
| SCHEMBL7464447 | 0.76 | PIK3CA (0.62) | SRCPIK3CGPIK3CAPIK3CBABL1 | |
| SCHEMBL7660259 | 0.74 | AGER (0.55) | AGERSRCYES1PIK3CGPIK3CA | |
| SCHEMBL18304247 | 0.74 | AGER (1.00) | AGERSRCYES1PIK3CGPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |