SCHEMBL7464967

SCHEMBL7464967

Cn1nnc(-c2ccc(CN3CCC(C(O)(c4ccc(C(F)(F)F)cc4)c4ccc(C(F)(F)F)cc4)CC3)cc2)n1

nearest known ligand 0.54

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
DNMT1 P26358 1/20 0.54
EHMT2 Q96KQ7 1/20 0.54
KCNH2 Q12809 2/20 0.53
HRH1 P35367 1/20 0.49
CHKA P35790 1/20 0.47
HDAC6 Q9UBN7 1/20 0.45
CCR5 P51681 1/20 0.44
DRD2 P14416 1/20 0.43
DRD4 P21917 1/20 0.43
DRD3 P35462 1/20 0.43
BCHE P06276 1/20 0.43
ACHE P22303 1/20 0.43
BACE1 P56817 1/20 0.43
ALDH1A1 P00352 2/20 0.41
CYP3A4 P08684 1/20 0.41
KDM4E B2RXH2 1/20 0.41
CHRM4 P08173 1/20 0.41
GPR119 Q8TDV5 1/20 0.41
LMNA P02545 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7466544 0.89 ALDH1A1 (0.49) DNMT1EHMT2KCNH2HRH1CCR5
SCHEMBL7470504 0.89 KCNH2 (0.52) DNMT1EHMT2KCNH2HRH1CHKA
SCHEMBL7469010 0.89 DNMT1 (0.53) DNMT1EHMT2KCNH2HRH1CHKA
SCHEMBL7469624 0.82 KCNH2 (0.61) DNMT1EHMT2KCNH2HRH1DRD2
SCHEMBL7472407 0.81 ALDH1A1 (0.39) DNMT1EHMT2KCNH2CHKAHDAC6
SCHEMBL7470569 0.78 HDAC6 (0.43) DNMT1EHMT2KCNH2HRH1CHKA
SCHEMBL7976493 0.76 KCNH2 (0.45) DNMT1EHMT2KCNH2HRH1HDAC6
SCHEMBL2611120 0.76 ALDH1A1 (0.55) HDAC6ALDH1A1KDM4ELMNA
Hydrochloric Acid SCHEMBL8200558 0.75 KCNH2 (0.67) DNMT1EHMT2KCNH2HRH1BCHE
SCHEMBL7990602 0.75 KCNH2 (0.45) DNMT1EHMT2KCNH2HRH1DRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0844825-B1 INSECTICIDAL N-(SUBSTITUTED ARYLMETHYL)-4- BIS(SUBSTITUTED PHENYL OR PYRIDYL)METHYL]PIPERIDINES FMC CORP (US) 2002-11-27 EP claimed
EP-0844825-A4 INSECTICIDAL N-(SUBSTITUTED ARYLMETHYL)-4- BIS(SUBSTITUTED PHENYL OR PYRIDYL)METHYL]PIPERIDINES FMC CORP (US) 2000-04-05 EP claimed
EP-0844825-A1 INSECTICIDAL N-(SUBSTITUTED ARYLMETHYL)-4- BIS(SUBSTITUTED PHENYL OR PYRIDYL)METHYL]PIPERIDINES FMC CORPORATION (US) 1998-06-03 EP claimed
WO-1996036228-A1 INSECTICIDAL N-(SUBSTITUTED ARYLMETHYL)-4-[BIS(SUBSTITUTED PHENYL OR PYRIDYL)METHYL]PIPERIDINES FMC CORPORATION (US) 1996-11-21 WO claimed
EP-0844825-B1 INSECTICIDAL N-(SUBSTITUTED ARYLMETHYL)-4- BIS(SUBSTITUTED PHENYL OR PYRIDYL)METHYL]PIPERIDINES FMC CORP (US) 2002-11-27 EP disclosed
US-6214845-B1 AGRICULTURE FMC CORPORATION 2001-04-10 US disclosed
US-6184234-B1 EFFECTIVE AGRICULTURAL PESTICIDE FOR TOBACCO, BEETS, BEANS, CABBAGE CROPS FMC CORPORATION 2001-02-06 US disclosed
EP-0844825-A4 INSECTICIDAL N-(SUBSTITUTED ARYLMETHYL)-4- BIS(SUBSTITUTED PHENYL OR PYRIDYL)METHYL]PIPERIDINES FMC CORP (US) 2000-04-05 EP disclosed
US-6030987-A Insecticidal N-(substituted arylmethyl)-4-[bis(substituted phenyl or pyridyl)methyl]piperidines FMC CORPORATION (US) 2000-02-29 US disclosed
EP-0844825-A1 INSECTICIDAL N-(SUBSTITUTED ARYLMETHYL)-4- BIS(SUBSTITUTED PHENYL OR PYRIDYL)METHYL]PIPERIDINES FMC CORPORATION (US) 1998-06-03 EP disclosed
WO-1996036228-A1 INSECTICIDAL N-(SUBSTITUTED ARYLMETHYL)-4-[BIS(SUBSTITUTED PHENYL OR PYRIDYL)METHYL]PIPERIDINES FMC CORPORATION (US) 1996-11-21 WO disclosed
US-5569664-A AGRICULTURAL INSECTICIDES FMC CORPORATION (US) 1996-10-29 US disclosed