Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.35 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.34 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7465874 | 0.81 | AKR1B1 (0.50) | CMA1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7465240 | 0.80 | CMA1 (0.44) | CMA1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7463225 | 0.77 | CMA1 (0.42) | CMA1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7472833 | 0.76 | MAPT (0.48) | CMA1ALDH1A1TSHRHTTMAPT | |
| SCHEMBL7470400 | 0.75 | AKR1B1 (0.49) | CMA1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7471563 | 0.75 | PPARG (0.48) | CMA1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7467388 | 0.75 | PSEN1 (0.42) | CMA1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7467040 | 0.74 | CMA1 (0.43) | CMA1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7563746 | 0.74 | MAPT (0.49) | KDM4EALDH1A1HPGDMAPTHDAC6 | |
| SCHEMBL7459066 | 0.74 | KMT2A (0.54) | ALDH1A1TSHRHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795548-B1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LTD (JP) | 2002-07-03 | — | — | EP | disclosed |
| US-5814631-A | CHYMASE INHIBITOR, CARDIVASCULAR | SUNTORY LIMITED (JP) | 1998-09-29 | — | — | US | disclosed |
| EP-0795548-A1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LIMITED (JP) | 1997-09-17 | — | — | EP | disclosed |