Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 6/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7469653 | 0.85 | HDAC6 (0.43) | MAPTMAPK8MAPK9HTR6TP53 | |
| SCHEMBL7472833 | 0.83 | MAPT (0.48) | CMA1MAPTTP53USP2SMN1; SMN2 | |
| SCHEMBL7465874 | 0.81 | AKR1B1 (0.50) | CMA1HDAC6PSEN1PSEN2APH1B | |
| SCHEMBL7463225 | 0.81 | CMA1 (0.42) | CMA1MAPTTP53HDAC6SMN1; SMN2 | |
| SCHEMBL7563746 | 0.80 | MAPT (0.49) | MAPTTP53HDAC6POLB | |
| SCHEMBL7459066 | 0.80 | KMT2A (0.54) | MAPTTP53SMN1; SMN2 | |
| SCHEMBL7468006 | 0.80 | MAPT (0.46) | CMA1MAPTTP53SMN1; SMN2POLB | |
| SCHEMBL7468103 | 0.79 | GAA (0.44) | CMA1MAPTTP53SMN1; SMN2 | |
| SCHEMBL7465395 | 0.79 | TP53 (0.51) | CMA1MAPTTP53HDAC6SMN1; SMN2 | |
| SCHEMBL7465177 | 0.78 | S1PR2 (0.49) | CMA1MAPTTP53HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795548-B1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LTD (JP) | 2002-07-03 | — | — | EP | disclosed |
| EP-0795548-A1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LIMITED (JP) | 1997-09-17 | — | — | EP | disclosed |