Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | CCR4 | P51679 | 4/20 | 0.33 |
| ▸ | NPY1R | P25929 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.31 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8935311 | 0.96 | SMN1; SMN2 (0.32) | SMN1; SMN2HIF1ACCR4NPY1RALDH1A1 | |
| SCHEMBL7467654 | 0.85 | NPY1R (0.37) | SMN1; SMN2HIF1ACCR4NPY1RALDH1A1 | |
| SCHEMBL7466587 | 0.85 | CCR4 (0.36) | SMN1; SMN2HIF1ACCR4NPY1RALDH1A1 | |
| SCHEMBL7468793 | 0.84 | CCR4 (0.36) | SMN1; SMN2HIF1ACCR4NPY1RALDH1A1 | |
| SCHEMBL7470948 | 0.84 | GLP1R (0.33) | SMN1; SMN2HIF1ACCR4NPY1RALDH1A1 | |
| SCHEMBL7475650 | 0.81 | CCR4 (0.35) | CCR4KDM4EMAPTPIK3CAPIK3CD | |
| SCHEMBL7476942 | 0.79 | ALDH1A1 (0.38) | SMN1; SMN2HIF1ACCR4NPY1RALDH1A1 | |
| SCHEMBL7462801 | 0.78 | CCR4 (0.36) | SMN1; SMN2HIF1ACCR4BRAFLMNA | |
| SCHEMBL8935248 | 0.78 | PIK3CA (0.32) | PIK3CA | |
| SCHEMBL7468982 | 0.76 | ALDH1A1 (0.45) | SMN1; SMN2HIF1ANPY1RALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783495-B1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | PFIZER LTD (GB) | 2002-02-27 | — | — | EP | disclosed |
| US-5863917-A | ANXIOLYTIC AGENT, ANTICONVULSANTS, ANALGESICS AND NEUROPROTECTIVES. | PFIZER, INC. (US) | 1999-01-26 | — | — | US | disclosed |
| US-5852016-A | Quinoxaline derivatives useful in therapy | PFIZER INC. (US) | 1998-12-22 | — | — | US | disclosed |
| WO-1997031902-A1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | PFIZER RESEARCH AND DEVELOPMENT COMPANY, N.V./S.A. (IE) | 1997-09-04 | — | — | WO | disclosed |
| EP-0792874-A1 | Quinoxaline derivatives useful in therapy | Pfizer Limited (GB) | 1997-09-03 | — | — | EP | disclosed |
| EP-0783495-A1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | Pfizer Limited (GB) | 1997-07-16 | — | — | EP | disclosed |
| WO-1996009295-A1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | PFIZER LIMITED (GB) | 1996-03-28 | — | — | WO | disclosed |