Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4969090 | 1.00 | FDPS (0.50) | FDPSKDM4EHTTNPSR1L3MBTL1 | |
| SCHEMBL4969096 | 1.00 | FDPS (0.50) | FDPSKDM4EHTTNPSR1L3MBTL1 | |
| SCHEMBL24568583 | 0.83 | HCAR3 (0.50) | FDPSKDM4EHTTNPSR1L3MBTL1 | |
| SCHEMBL6442872 | 0.83 | HCAR3 (0.50) | FDPSKDM4EHTTNPSR1L3MBTL1 | |
| SCHEMBL19581191 | 0.81 | KDM4E (0.46) | FDPSKDM4EHTTNPSR1L3MBTL1 | |
| SCHEMBL1831586 | 0.81 | KDM4E (0.46) | FDPSKDM4EHTTNPSR1L3MBTL1 | |
| SCHEMBL21018364 | 0.80 | TLR8 (0.47) | FDPSKDM4EHTTNPSR1L3MBTL1 | |
| SCHEMBL6439928 | 0.80 | TLR8 (0.47) | FDPSKDM4EHTTNPSR1L3MBTL1 | |
| SCHEMBL9645509 | 0.80 | CYP2D6 (0.54) | FDPSKDM4EHTTNPSR1L3MBTL1 | |
| SCHEMBL18190268 | 0.80 | POLB (0.51) | FDPSKDM4EHTTNPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6133449-A | Processes and intermediates for the preparation of piperazine derivatives | JOHN WYETH & BROTHER LTD. (GB) | 2000-10-17 | — | — | US | claimed |
| EP-0763024-A1 | NOVEL PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF PIPERAZINE DERIVATIVES | JOHN WYETH & BROTHER LIMITED (GB) | 1997-03-19 | — | — | EP | claimed |
| WO-1995033725-A1 | NOVEL PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF PIPERAZINE DERIVATIVES | JOHN WYETH & BROTHER LIMITED (GB) | 1995-12-14 | — | — | WO | claimed |
| CN-1093122-C | Piperazine derivatives as 5-HT1A antagonists | WYETH JOHN & BROTHER LTD (GB) | 2002-10-23 | — | — | CN | disclosed |
| EP-0763024-B1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF PIPERAZINE DERIVATIVES | WYETH JOHN & BROTHER LTD (GB) | 2002-08-14 | — | — | EP | disclosed |
| US-6395902-B1 | NOVEL INTERMEDIATES IN THE PREPARATION OF PHARMACEUTICALLY USEFUL PYRIDINE DERIVATIVES AS END COMPOUNDS | JOHN WYETH & BROTHER LIMITED (GB) | 2002-05-28 | — | — | US | disclosed |
| US-6175012-B1 | REACTING 4-METHYL-3-(2-PYRIDYL)-(1,2,3,)OXATHIAZOLIDINE-2,2-DIOXIDE, FOR EXAMPLE WITH A 1-(ARYL OR HETEROARYL)PIPERAZINE TO FORM A 1-(HETERO)ARYL-4-(HETEROARYLAMINOALKYL)PIPERAZINE; INTERMEDIATE TO 5-HT1A ANTAGONIST DRUGS | JOHN WYETH & BROTHER LTD. (GB) | 2001-01-16 | — | — | US | disclosed |
| US-6133449-A | Processes and intermediates for the preparation of piperazine derivatives | JOHN WYETH & BROTHER LTD. (GB) | 2000-10-17 | — | — | US | disclosed |
| EP-0763031-B1 | PIPERAZINE DERIVATIVES AS 5HT1A ANTAGONISTS | WYETH JOHN & BROTHER LTD (GB) | 2000-05-10 | — | — | EP | disclosed |
| CN-1048985-C | As 5-HT1APiperazine derivatives of antagonists | WYETH JOHN & BROTHER LTD (GB) | 2000-02-02 | — | — | CN | disclosed |
| CN-1227841-A | Piperazine derivatives as 5-HT1A antagonists | WYETH JOHN & BROTHER LTD (GB) | 1999-09-08 | — | — | CN | disclosed |
| US-5723464-A | CENTRAL NERVOUS SYSTEM DISORDERS, ANXIETY OR DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-03-03 | — | — | US | disclosed |
| CN-1149873-A | As 5-HT1APiperazine derivatives of antagonists | WYETH JOHN & BROTHER LTD (GB) | 1997-05-14 | — | — | CN | disclosed |
| EP-0763024-A1 | NOVEL PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF PIPERAZINE DERIVATIVES | JOHN WYETH & BROTHER LIMITED (GB) | 1997-03-19 | — | — | EP | disclosed |
| EP-0763031-A1 | PIPERAZINE DERIVATIVES AS 5HT1A ANTAGONISTS | JOHN WYETH & BROTHER LIMITED (GB) | 1997-03-19 | — | — | EP | disclosed |
| WO-1995033725-A1 | NOVEL PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF PIPERAZINE DERIVATIVES | JOHN WYETH & BROTHER LIMITED (GB) | 1995-12-14 | — | — | WO | disclosed |
| WO-1995033743-A1 | PIPERAZINE DERIVATIVES AS 5HT1A ANTAGONISTS | JOHN WYETH & BROTHER LIMITED (GB) | 1995-12-14 | — | — | WO | disclosed |