Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 12/20 | 0.57 |
| ▸ | DRD2 | P14416 | 11/20 | 0.57 |
| ▸ | HTR2A | P28223 | 2/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7452193 | 0.88 | HTR1A (0.57) | HTR1ADRD2HTR2AOPRM1OPRK1 | |
| SCHEMBL7455854 | 0.88 | HTR1A (0.60) | HTR1ADRD2HTR2AOPRM1OPRK1 | |
| SCHEMBL7461126 | 0.86 | HTR1A (0.53) | HTR1ADRD2HTR2AOPRM1OPRK1 | |
| SCHEMBL7456118 | 0.81 | HTR1A (0.49) | HTR1ADRD2HTR2A | |
| SCHEMBL7649906 | 0.81 | HTR1A (0.83) | HTR1ADRD2HTR2AOPRM1OPRK1 | |
| SCHEMBL5365266 | 0.78 | SLC6A4 (0.69) | HTR1ADRD2HTR2A | |
| SCHEMBL6133368 | 0.76 | DRD2 (0.71) | HTR1ADRD2HTR2ADRD4DRD3 | |
| Bromide SCHEMBL9049971 | 0.76 | HTR1A (0.51) | HTR1ADRD2HTR2ASIGMAR1 | |
| Phthalic Acid SCHEMBL9045536 | 0.76 | OPRM1 (0.53) | HTR1ADRD2OPRM1OPRK1 | |
| Phthalic Acid SCHEMBL30909196 | 0.76 | OPRM1 (0.53) | HTR1ADRD2OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708102-B1 | 5-HT1F agonists for the treatment of migraine | LILLY CO ELI (US) | 2002-12-11 | — | — | EP | disclosed |
| EP-0708102-A1 | 5-HT1F agonists for the treatment of migraine | ELI LILLY AND COMPANY (US) | 1996-04-24 | — | — | EP | disclosed |