Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7470143 | 0.76 | MAPT (0.36) | LMNACYP1A2CYP3A4MAOASLC6A4 | |
| SCHEMBL7473202 | 0.75 | HRH3 (0.34) | LMNACYP1A2CYP3A4MAOASLC6A4 | |
| SCHEMBL7473197 | 0.68 | HRH3 (0.33) | SLC6A4SLC6A2SLC6A3CYP2D6PTGER4 | |
| SCHEMBL6309219 | 0.64 | ADRB1 (0.39) | LMNACYP1A2CYP3A4MAOAALOX15 | |
| SCHEMBL4585642 | 0.63 | LOXL2 (0.39) | SLC6A4SLC6A2SLC6A3KCNH2RAB9A | |
| SCHEMBL27574703 | 0.62 | CA12 (0.45) | LMNACYP1A2CYP3A4MAOASLC6A4 | |
| SCHEMBL15231562 | 0.62 | ESR2 (0.51) | LMNACYP1A2CYP3A4MAOARAB9A | |
| SCHEMBL4585644 | 0.61 | MAPT (0.40) | SLC6A4SLC6A2SLC6A3KCNH2MAPT | |
| Hydrochloric Acid SCHEMBL15231866 | 0.61 | ESR2 (0.50) | LMNACYP1A2CYP3A4MAOACYP2D6 | |
| Benzocaine SCHEMBL11645997 | 0.60 | LMNA (0.75) | LMNACYP1A2CYP3A4MAOASLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214313-A2 | HETEROARYLOXY PROPANOLAMINES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI-SYNTHELABO (FR) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001017989-A2 | HETEROARYLOXYPROPANOLAMINES AS BETA3-ADRENERGIC RECEPTOR AGONISTS | SANOFI-SYNTHELABO (FR) | 2001-03-15 | — | — | WO | disclosed |