Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 4/20 | 0.41 |
| ▸ | DRD2 | P14416 | 4/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7467130 | 0.88 | HTR1A (0.51) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL7467112 | 0.88 | HTR1A (0.51) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL7466182 | 0.87 | ADRA1D (0.42) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL7468004 | 0.87 | ADRA2A (0.52) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL7464370 | 0.85 | HTR1A (0.46) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL7461438 | 0.85 | HTR1A (0.56) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL7463410 | 0.85 | HTR1A (0.52) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL7472103 | 0.84 | HTR1A (0.54) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL7463528 | 0.83 | HTR1A (0.51) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL6975068 | 0.82 | ADRA1D (0.67) | ADRA1DADRA1AADRA1BHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876372-B1 | HETEROARYLCARBOXAMIDE DERIVATIVES | KNOLL GMBH (DE) | 2002-03-06 | — | — | EP | claimed |
| US-6107310-A | PSYCHOLOGICAL DISORDERS | KNOLL AKTIENGESELLSCHAFT (DE) | 2000-08-22 | — | — | US | claimed |
| EP-0876372-B1 | HETEROARYLCARBOXAMIDE DERIVATIVES | KNOLL GMBH (DE) | 2002-03-06 | — | — | EP | disclosed |
| US-6107310-A | PSYCHOLOGICAL DISORDERS | KNOLL AKTIENGESELLSCHAFT (DE) | 2000-08-22 | — | — | US | disclosed |
| EP-0876372-A1 | HETEROARYLCARBOXAMIDE DERIVATIVES | KNOLL AKTIENGESELLSCHAFT (DE) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997023485-A1 | HETEROARYLCARBOXAMIDE DERIVATIVES | KNOLL AKTIENGESELLSCHAFT (DE) | 1997-07-03 | — | — | WO | disclosed |