Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR1E | P28566 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7481405 | 0.82 | NR1H2 (0.42) | NR1H2ESR2NPC1RAB9AITGB3 | |
| SCHEMBL7468291 | 0.82 | NR1H2 (0.38) | NR1H2ESR2TMEM97SIGMAR1HTR1A | |
| SCHEMBL7419930 | 0.81 | NR1H2 (0.49) | NR1H2ESR2TMEM97SIGMAR1NPC1 | |
| SCHEMBL7479149 | 0.81 | ITGB3 (0.40) | TMEM97SIGMAR1HTR1ACHRM5SLC6A2 | |
| SCHEMBL7381195 | 0.80 | ITGB3 (0.56) | TMEM97SIGMAR1HTR1ACHRM5SLC6A2 | |
| SCHEMBL7474864 | 0.78 | TMEM97 (0.39) | NR1H2ESR2TMEM97SIGMAR1HTR1A | |
| SCHEMBL7473247 | 0.78 | NR1H2 (0.47) | NR1H2ESR2TMEM97SIGMAR1NPC1 | |
| SCHEMBL7474006 | 0.77 | ITGB3 (0.38) | TMEM97SIGMAR1HTR1ACHRM5SLC6A2 | |
| SCHEMBL7468971 | 0.76 | ITGB3 (0.42) | NR1H2ESR2NPC1RAB9AITGB3 | |
| SCHEMBL7474275 | 0.76 | ITGB3 (0.51) | RAB9AITGB3ITGA2BKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0777667-A1 | CYCLIC BENZAZEPINE UREA DERIVATIVES WITH AGGREGATION-INHIBITING EFFECT | Dr. Karl Thomae GmbH (DE) | 1997-06-11 | — | — | EP | disclosed |
| WO-1996005194-A1 | CYCLIC BENZAZEPINE UREA DERIVATIVES WITH AGGREGATION-INHIBITING EFFECT | DR. KARL THOMAE GMBH (DE) | 1996-02-22 | — | — | WO | disclosed |