Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8540903 | 0.82 | HRH3 (0.33) | HRH3 | |
| SCHEMBL15428837 | 0.72 | SIGMAR1 (0.33) | HRH3SIGMAR1 | |
| SCHEMBL14594807 | 0.68 | SIGMAR1 (0.31) | SIGMAR1 | |
| SCHEMBL31678783 | 0.67 | CHRNA3 (0.36) | HRH3CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL14011291 | 0.64 | MEN1 (0.51) | CHRNA7 | |
| SCHEMBL14011287 | 0.64 | MEN1 (0.51) | CHRNA7 | |
| SCHEMBL19818335 | 0.62 | SLC6A2 (0.46) | HRH3HTR3ASIGMAR1 | |
| Hydrochloric Acid SCHEMBL11364324 | 0.62 | KDM1A (0.38) | CHRNB4CHRNA3CHRNB2 | |
| SCHEMBL11190854 | 0.62 | CHRNA7 (0.42) | HRH3CHRNA7 | |
| SCHEMBL11190856 | 0.62 | CHRNA7 (0.42) | HRH3CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0740657-B1 | 4-ARYLISOINDOLE ANALGESICS | ORTHO PHARMA CORP (US) | 2002-03-06 | — | — | EP | disclosed |
| US-5543530-A | 4-arylisoindole analgesics | ORTHO PHARMACEUTICAL CORPORATION (US) | 1996-08-06 | — | — | US | disclosed |