Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7466006 | 0.82 | HRH3 (0.42) | HRH3 | |
| SCHEMBL15428837 | 0.68 | SIGMAR1 (0.33) | HRH3 | |
| SCHEMBL3058175 | 0.66 | HRH3 (0.74) | HRH3KCNH2 | |
| SCHEMBL23605127 | 0.65 | PTGS2 (0.33) | HRH3ALDH1A1HPGDHSD17B10 | |
| SCHEMBL14594807 | 0.64 | SIGMAR1 (0.31) | — | |
| SCHEMBL8539768 | 0.64 | SLC6A4 (0.36) | ALDH1A1HPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL9530988 | 0.63 | SLC18A3 (0.31) | DRD2DRD4 | |
| SCHEMBL10300271 | 0.59 | ALDH1A1 (0.50) | ALDH1A1 | |
| SCHEMBL10528160 | 0.59 | ALDH1A1 (0.50) | ALDH1A1 | |
| SCHEMBL8967524 | 0.58 | ALDH1A1 (0.32) | ALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690842-B1 | 4-ARYLISOINDOLE ANALGESICS | ORTHO PHARMA CORP (US) | 1998-12-16 | — | — | EP | disclosed |
| US-5508424-A | REDUCED SIDE EFFECTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1996-04-16 | — | — | US | disclosed |