Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.64 |
| ▸ | BCR | P11274 | 2/20 | 0.64 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.64 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.64 |
| ▸ | PRKCA | P17252 | 1/20 | 0.64 |
| ▸ | SYK | P43405 | 13/20 | 0.63 |
| ▸ | CDK2 | P24941 | 2/20 | 0.63 |
| ▸ | SRC | P12931 | 1/20 | 0.63 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.63 |
| ▸ | CDK1 | P06493 | 2/20 | 0.61 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.61 |
| ▸ | RET | P07949 | 1/20 | 0.61 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.61 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.61 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.60 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.57 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7464938 | 0.89 | KDR (0.64) | ABL1BCRPRKCASYKCDK2 | |
| SCHEMBL7465887 | 0.85 | ABL1 (0.70) | ABL1BCRPIK3CAPIK3CGPRKCA | |
| SCHEMBL7470857 | 0.84 | ABL1 (0.63) | ABL1BCRPRKCASYKCDK2 | |
| SCHEMBL4903508 | 0.83 | ABL1 (0.67) | ABL1BCRPRKCASYKCDK2 | |
| SCHEMBL7469928 | 0.83 | ABL1 (0.64) | ABL1BCRPIK3CAPIK3CGPRKCA | |
| SCHEMBL5734023 | 0.83 | ABL1 (0.64) | ABL1BCRPRKCASYKCDK2 | |
| SCHEMBL7461176 | 0.83 | SYK (0.62) | ABL1BCRPRKCASYK | |
| SCHEMBL7468137 | 0.83 | ABL1 (0.60) | ABL1BCRPRKCASYKCDK2 | |
| SCHEMBL7466253 | 0.83 | PIK3CG (0.71) | ABL1BCRPIK3CAPIK3CGPRKCA | |
| SCHEMBL2823600 | 0.82 | KCNN1 (0.62) | ABL1BCRPRKCASYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |