Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.32 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7468693 | 0.92 | MAPT (0.37) | BACE1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7462091 | 0.82 | TP53 (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8784743 | 0.80 | ALDH3A1 (0.43) | BACE1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7460693 | 0.79 | CMA1 (0.40) | BACE1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7461905 | 0.78 | CMA1 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7472829 | 0.78 | CMA1 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7472664 | 0.75 | GAA (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7471528 | 0.75 | CMA1 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7468000 | 0.74 | CMA1 (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7468036 | 0.74 | NOD1 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795548-B1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LTD (JP) | 2002-07-03 | — | — | EP | disclosed |
| EP-0795548-A1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LIMITED (JP) | 1997-09-17 | — | — | EP | disclosed |