Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.40 |
| ▸ | KRAS | P01116 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | FBP1 | P09467 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7463550 | 0.85 | ACHE (0.40) | EGFRPDGFRBABCG2SOS1KRAS | |
| SCHEMBL7465511 | 0.80 | EGFR (0.48) | EGFRPDGFRBABCG2SOS1KRAS | |
| SCHEMBL7475452 | 0.79 | EGFR (0.52) | EGFRPDGFRBABCG2SOS1KRAS | |
| SCHEMBL7473900 | 0.78 | EGFR (0.56) | EGFRPDGFRBABCG2SOS1KRAS | |
| SCHEMBL7474113 | 0.75 | EGFR (0.55) | EGFRPDGFRBABCG2FBP1 | |
| SCHEMBL7460872 | 0.75 | EGFR (0.47) | EGFRPDGFRBABCG2CNR1 | |
| SCHEMBL7529433 | 0.75 | EGFR (0.51) | EGFRPDGFRBABCG2SOS1KRAS | |
| SCHEMBL7470644 | 0.75 | EGFR (0.53) | EGFRPDGFRBABCG2SOS1KRAS | |
| SCHEMBL7460996 | 0.74 | EGFR (0.48) | EGFRPDGFRBABCG2SOS1KRAS | |
| SCHEMBL7472380 | 0.73 | EGFR (0.53) | EGFRPDGFRBABCG2FBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1229025-A1 | NOVEL QUINAZOLINE DERIVATIVES | Japan Energy Corporation (JP) | 2002-08-07 | — | — | EP | disclosed |