Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
| ▸ | CBFB | Q13951 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7468146 | 0.88 | DHFR (0.48) | ADORA1ADORA2ACBFBACVR1BTGFBR1 | |
| SCHEMBL7462501 | 0.83 | ADORA1 (0.60) | MEN1ALOX15TSHRKMT2AADORA1 | |
| SCHEMBL7466847 | 0.82 | ADORA1 (0.50) | MEN1ALOX15TSHRKMT2AADORA1 | |
| SCHEMBL7535601 | 0.80 | CYP1A2 (0.46) | MEN1ALOX15KMT2AADORA1ADORA2A | |
| SCHEMBL5450249 | 0.80 | ADORA1 (0.70) | ALOX15KMT2AADORA1ADORA2ANPC1 | |
| SCHEMBL6824538 | 0.75 | KDM4E (0.50) | ALOX15ADORA1ADORA2ANPC1LMNA | |
| SCHEMBL23105481 | 0.74 | MEN1 (0.60) | MEN1ALOX15TSHRKMT2ANPC1 | |
| SCHEMBL7463419 | 0.72 | ADORA1 (0.59) | ADORA1ADORA2ACYP19A1CDK5CDK5R1 | |
| SCHEMBL7471063 | 0.72 | RAB9A (0.70) | MEN1ALOX15TSHRKMT2AADORA2A | |
| SCHEMBL7471062 | 0.71 | ABL1 (0.51) | ALOX15TSHRADORA1ADORA2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |