Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.64 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.64 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.64 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.64 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.50 |
| ▸ | KDM5C | P41229 | 3/20 | 0.48 |
| ▸ | PHF8 | Q9UPP1 | 3/20 | 0.48 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | OR51E2 | Q9H255 | 2/20 | 0.47 |
| ▸ | CTH | P32929 | 1/20 | 0.47 |
| ▸ | CBS | P35520 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.47 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adipic Acid SCHEMBL27483779 | 0.87 | LMNA (0.69) | LMNAGABRR1TSHROR51E2SLC22A6 | |
| Succinic Acid SCHEMBL28729193 | 0.81 | LMNA (0.82) | LMNAEGLN1ALKBH5SUCNR1GABRR1 | |
| Succinic Acid SCHEMBL1655131 | 0.81 | LMNA (0.82) | LMNAEGLN1ALKBH5SUCNR1GABRR1 | |
| Succinic Acid SCHEMBL27804789 | 0.81 | LMNA (0.82) | LMNAEGLN1ALKBH5SUCNR1GABRR1 | |
| Succinic Acid SCHEMBL28156291 | 0.81 | LMNA (0.82) | LMNAEGLN1ALKBH5SUCNR1GABRR1 | |
| Succinic Acid SCHEMBL7752977 | 0.81 | LMNA (0.82) | LMNAEGLN1ALKBH5SUCNR1GABRR1 | |
| Succinic Acid SCHEMBL829 | 0.80 | — | — | |
| Succinic Acid SCHEMBL4269130 | 0.80 | LMNA (1.00) | LMNAEGLN1ALKBH5SUCNR1GABRR1 | |
| Succinic Acid SCHEMBL21867134 | 0.80 | LMNA (1.00) | LMNAEGLN1ALKBH5SUCNR1GABRR1 | |
| Succinic Acid SCHEMBL1331200 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101535385-B | Water-soluble film | MONOSOL LLC | 2013-02-13 | — | — | CN | disclosed |
| CN-101535385-A | Water-soluble film | MONOSOL LLC (US) | 2009-09-16 | — | — | CN | disclosed |
| EP-1196451-A4 | SURFACE MODIFICATION OF VULCANISED RUBBER OBJECTS | COMMW SCIENT IND RES ORG (AU) | 2002-10-24 | — | — | EP | disclosed |
| US-20020074696-A1 | Surface modification of vulcanised rubber objects | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 2002-06-20 | — | — | US | disclosed |
| EP-1196451-A1 | SURFACE MODIFICATION OF VULCANISED RUBBER OBJECTS | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 2002-04-17 | — | — | EP | disclosed |
| WO-2000053638-A1 | SURFACE MODIFICATION OF VULCANISED RUBBER OBJECTS | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 2000-09-14 | — | — | WO | disclosed |