Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 0.70 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.67 |
| ▸ | PTGES | O14684 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | PDE5A | O76074 | 1/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CA3 | P07451 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7465512 | 0.84 | PTGS2 (0.71) | PTGS2PTGS1 | |
| SCHEMBL7472447 | 0.83 | PTGS2 (0.60) | PTGS2PTGS1CYP2C9CYP3A4TSHR | |
| SCHEMBL6343314 | 0.83 | PTGS2 (1.00) | PTGS2PTGS1CYP2C9PTGESHDAC3 | |
| SCHEMBL6166763 | 0.83 | PTGS2 (0.67) | PTGS2PTGS1CYP2C9 | |
| SCHEMBL6883977 | 0.82 | PTGS2 (0.62) | PTGS2PTGS1CYP2C9 | |
| SCHEMBL7466367 | 0.82 | PTGS2 (0.55) | PTGS2PTGS1CYP2C9CA12CA1 | |
| SCHEMBL6164309 | 0.81 | PTGS2 (0.63) | PTGS2 | |
| SCHEMBL9089487 | 0.81 | PTGS2 (0.52) | PTGS2PTGS1CA12CA1CA2 | |
| SCHEMBL8953888 | 0.80 | PTGS2 (1.00) | PTGS2PTGS1CYP2C9PTGESHDAC3 | |
| SCHEMBL5229949 | 0.80 | PTGS2 (1.00) | PTGS2PTGS1CYP2C9PTGESHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0554829-B1 | Pyrazole derivatives with antiinflammatory, analgesic and antithrombolic activity | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-05-15 | — | — | EP | disclosed |
| US-5550147-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTITHROMBOTIC AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-08-27 | — | — | US | disclosed |
| EP-0554829-A2 | Pyrazole derivatives with antiinflammatory, analgesic and antithrombolic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-08-11 | — | — | EP | disclosed |