Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 15/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.60 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7467786 | 0.83 | PTGS2 (0.70) | PTGS2PTGS1CYP2C9CYP3A4TSHR | |
| SCHEMBL7462937 | 0.82 | PTGS2 (0.59) | PTGS2PTGS1NPSR1 | |
| SCHEMBL6540417 | 0.80 | PTGS2 (0.57) | PTGS2PTGS1CYP2C9CYP1A2CYP3A4 | |
| SCHEMBL25150243 | 0.80 | PTGS2 (0.72) | PTGS2PTGS1CYP2C9CYP3A4TSHR | |
| SCHEMBL9273738 | 0.80 | PTGS2 (0.72) | PTGS2PTGS1CYP2C9CYP1A2CYP3A4 | |
| SCHEMBL9208582 | 0.79 | PTGS2 (0.74) | PTGS2PTGS1CYP2C9CYP3A4TSHR | |
| SCHEMBL5147701 | 0.79 | PTGS2 (0.71) | PTGS2PTGS1CYP2C9CYP1A2CYP3A4 | |
| SCHEMBL4032238 | 0.78 | PTGS1 (0.74) | PTGS2PTGS1CYP2C9CYP1A2CYP3A4 | |
| SCHEMBL5147766 | 0.78 | PTGS2 (0.57) | PTGS2PTGS1CYP2C9CYP1A2CYP3A4 | |
| SCHEMBL9201352 | 0.77 | PTGS2 (0.68) | PTGS2PTGS1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0554829-B1 | Pyrazole derivatives with antiinflammatory, analgesic and antithrombolic activity | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-05-15 | — | — | EP | disclosed |
| US-5550147-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTITHROMBOTIC AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-08-27 | — | — | US | disclosed |
| EP-0554829-A2 | Pyrazole derivatives with antiinflammatory, analgesic and antithrombolic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-08-11 | — | — | EP | disclosed |