Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 15/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.55 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7467786 | 0.82 | PTGS2 (0.70) | PTGS2PTGS1ALOX5CYP2C9CA12 | |
| SCHEMBL7465512 | 0.81 | PTGS2 (0.71) | PTGS2PTGS1 | |
| SCHEMBL9203630 | 0.81 | PTGS2 (0.65) | PTGS2PTGS1ALOX5CYP2C9CA12 | |
| SCHEMBL7459996 | 0.81 | PTGS2 (0.62) | PTGS2PTGS1ALOX5CYP2C9CA1 | |
| SCHEMBL9089487 | 0.80 | PTGS2 (0.52) | PTGS2PTGS1ALOX5CA12CA1 | |
| SCHEMBL9201549 | 0.80 | PTGS2 (0.78) | PTGS2PTGS1NR3C2ALOX5CYP2C9 | |
| SCHEMBL9207728 | 0.80 | PTGS2 (0.64) | PTGS2PTGS1ALOX5CYP2C9CA1 | |
| SCHEMBL9203156 | 0.80 | PTGS2 (0.78) | PTGS2PTGS1NR3C2ALOX5CYP2C9 | |
| SCHEMBL27342072 | 0.79 | ALOX5 (0.61) | PTGS2PTGS1ALOX5CYP2C9 | |
| SCHEMBL9210069 | 0.79 | PTGS2 (0.60) | PTGS2PTGS1ALOX5CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0554829-B1 | Pyrazole derivatives with antiinflammatory, analgesic and antithrombolic activity | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-05-15 | — | — | EP | disclosed |
| US-5550147-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTITHROMBOTIC AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-08-27 | — | — | US | disclosed |
| EP-0554829-A2 | Pyrazole derivatives with antiinflammatory, analgesic and antithrombolic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-08-11 | — | — | EP | disclosed |