Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7050803 | 0.91 | ADRA1D (0.44) | ADRA1DMAPTMAPK8MEN1KMT2A | |
| SCHEMBL7616815 | 0.88 | SIRT2 (0.38) | SIRT2NR3C2ADRA1DMAPTMAPK8 | |
| SCHEMBL7467933 | 0.85 | RPS6KB1 (0.36) | ADRA1DMAPK8MEN1KMT2AALDH1A1 | |
| SCHEMBL27508047 | 0.82 | P2RX4 (0.42) | MAPTMEN1KMT2AALDH1A1GAA | |
| SCHEMBL7944531 | 0.82 | GPR52 (0.42) | DAO | |
| SCHEMBL27506801 | 0.81 | ICMT (0.38) | ADRA1DMEN1KMT2AALDH1A1GAA | |
| SCHEMBL27506423 | 0.80 | ADRA1D (0.43) | ADRA1DMAPTMAPK8MEN1KMT2A | |
| SCHEMBL7420567 | 0.80 | MEN1 (0.44) | ADRA1DMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL6612458 | 0.80 | PLA2G2A (0.44) | ADRA1DPARP1 | |
| SCHEMBL27507605 | 0.80 | PLA2G2A (0.39) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001066111-A1 | COMPOSITIONS CONTAINING POTENTIAL SPLA2 INHIBITORS FOR THE TREATMENT OF PAIN | ELI LILLY AND COMPANY (US) | 2001-09-13 | — | — | WO | disclosed |