Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 13/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | KCNE1 | P15382 | 3/20 | 0.40 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7464041 | 0.89 | SMN1; SMN2 (0.46) | TRPV1CYP3A4KCNE1KCNQ1PSMB5 | |
| SCHEMBL7478341 | 0.87 | ALDH1A1 (0.48) | TRPV1CYP3A4KCNE1KCNQ1KMT2A | |
| SCHEMBL7470001 | 0.86 | KCNE1 (0.42) | TRPV1CYP3A4KCNE1KCNQ1CYP2D6 | |
| SCHEMBL4623467 | 0.86 | TRPV1 (0.42) | TRPV1CYP3A4KCNE1KCNQ1ALDH1A1 | |
| SCHEMBL7477267 | 0.85 | ALDH1A1 (0.43) | TRPV1KCNE1KCNQ1KMT2AALDH1A1 | |
| SCHEMBL7476073 | 0.84 | KCNE1 (0.40) | TRPV1CYP3A4KCNE1KCNQ1KMT2A | |
| SCHEMBL7476659 | 0.83 | KCNE1 (0.40) | TRPV1CYP3A4KCNE1KCNQ1 | |
| SCHEMBL7468807 | 0.82 | KCNE1 (0.40) | TRPV1CYP3A4KCNE1KCNQ1KMT2A | |
| SCHEMBL7464899 | 0.82 | KCNE1 (0.40) | TRPV1CYP3A4KCNE1KCNQ1KMT2A | |
| SCHEMBL7468526 | 0.80 | KCNE1 (0.49) | TRPV1CYP3A4KCNE1KCNQ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0905131-B1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | AVENTIS PHARMA GMBH (DE) | 2002-04-10 | — | — | EP | disclosed |
| EP-0905131-A1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-03-31 | — | — | EP | disclosed |