Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KCNE1 | P15382 | 3/20 | 0.40 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4623467 | 0.90 | TRPV1 (0.42) | ALDH1A1SMN1; SMN2HPGDCYP3A4TRPV1 | |
| SCHEMBL7468844 | 0.87 | TRPV1 (0.42) | ALDH1A1SMN1; SMN2HPGDKMT2ACYP3A4 | |
| SCHEMBL7470001 | 0.86 | KCNE1 (0.42) | CYP3A4TRPV1KCNE1KCNQ1 | |
| SCHEMBL7476659 | 0.83 | KCNE1 (0.40) | CYP3A4TRPV1KCNE1KCNQ1 | |
| SCHEMBL7468807 | 0.82 | KCNE1 (0.40) | KMT2ACYP3A4TRPV1KCNE1KCNQ1 | |
| SCHEMBL7477267 | 0.82 | ALDH1A1 (0.43) | ALDH1A1KMT2ATRPV1POLBKCNE1 | |
| SCHEMBL7476073 | 0.81 | KCNE1 (0.40) | KMT2ACYP3A4TRPV1KCNE1KCNQ1 | |
| SCHEMBL7464899 | 0.80 | KCNE1 (0.40) | KMT2ACYP3A4TRPV1KCNE1KCNQ1 | |
| SCHEMBL7468526 | 0.80 | KCNE1 (0.49) | CYP3A4TRPV1KCNE1KCNQ1 | |
| SCHEMBL7477380 | 0.80 | TRPV1 (0.42) | ALDH1A1CYP3A4TRPV1KCNE1KCNQ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0905131-B1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | AVENTIS PHARMA GMBH (DE) | 2002-04-10 | — | — | EP | disclosed |
| US-5955607-A | TREATING CARDIOVASCULAR AND GASTROINTESTINAL DISORDERS | HOECHST MARION ROUSSEL DEUTSCHLAND (DE) | 1999-09-21 | — | — | US | disclosed |
| EP-0905131-A1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-03-31 | — | — | EP | disclosed |