Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KHK | P50053 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GPR3 | P46089 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | FDPS | P14324 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11389060 | 0.76 | KDM4E (0.41) | KDM4EALDH1A1MAPTKMT2AGPR3 | |
| SCHEMBL3622982 | 0.73 | MAPT (0.43) | KDM4EALDH1A1MAPTMEN1POLB | |
| SCHEMBL30200294 | 0.73 | MAPT (0.43) | KDM4EALDH1A1MAPTMEN1POLB | |
| SCHEMBL3170374 | 0.72 | ALDH1A1 (0.43) | KDM4EALDH1A1MAPTMEN1POLB | |
| SCHEMBL3244662 | 0.72 | KDM4E (0.41) | KDM4EALDH1A1MAPTGPR3EGFR | |
| SCHEMBL10380319 | 0.70 | CNR2 (0.51) | KDM4EALDH1A1KHKMAPTMEN1 | |
| SCHEMBL1651399 | 0.69 | PDE10A (0.44) | KDM4EALDH1A1MEN1KMT2AGPR3 | |
| SCHEMBL6615577 | 0.68 | KDM4E (0.46) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL9530110 | 0.68 | MBNL1 (0.50) | KDM4EALDH1A1MAPTELANEPKM | |
| Biphenyl SCHEMBL27928291 | 0.68 | GAA (0.42) | KDM4EALDH1A1MAPTMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183242-A2 | 1,4-BENZODIAZEPIN-2-ONES USEFUL AS HIV REVERSE TRANSCRIPTASE INHIBITORS | Du Pont Pharmaceuticals Company (US) | 2002-03-06 | — | — | EP | claimed |
| WO-2000073284-A2 | 1,4-BENZODIAZEPIN-2-ONES USEFUL AS HIV REVERSE TRANSCRIPTASE INHIBITORS | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-12-07 | — | — | WO | claimed |
| EP-1183242-A2 | 1,4-BENZODIAZEPIN-2-ONES USEFUL AS HIV REVERSE TRANSCRIPTASE INHIBITORS | Du Pont Pharmaceuticals Company (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000073284-A2 | 1,4-BENZODIAZEPIN-2-ONES USEFUL AS HIV REVERSE TRANSCRIPTASE INHIBITORS | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-12-07 | — | — | WO | disclosed |