SCHEMBL7469701

SCHEMBL7469701

O=Cc1ccc(O)cc1C1CCCC1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.41
ALDH1A1 P00352 1/20 0.41
ESR2 Q92731 4/20 0.41
ESR1 P03372 1/20 0.41
HSP90AB1 P08238 1/20 0.41
HSP90AA1 P07900 1/20 0.37
TRIM24 O15164 1/20 0.36
TYR P14679 1/20 0.36
TRIM33 Q9UPN9 1/20 0.36
CHRNB2 P17787 1/20 0.36
CHRNA4 P43681 1/20 0.36
POLB P06746 1/20 0.35
MAOB P27338 2/20 0.35
MAOA P21397 1/20 0.35
DYRK1A Q13627 1/20 0.34
HDAC4 P56524 1/20 0.34
HDAC2 Q92769 1/20 0.34
HDAC8 Q9BY41 1/20 0.34
NUDT1 P36639 1/20 0.34
BACE1 P56817 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29036666 0.98 MAPT (0.44) MAPTALDH1A1ESR2ESR1HSP90AB1
SCHEMBL21116526 0.98 ESR2 (0.39) MAPTALDH1A1ESR2ESR1HSP90AB1
SCHEMBL28225239 0.81 MAPT (0.44) MAPTALDH1A1ESR2ESR1HSP90AB1
SCHEMBL11153829 0.79 TDP1 (0.50) MAPTCHRNB2CHRNA4
SCHEMBL20183968 0.79 ALDH1A1 (0.36) ALDH1A1HSP90AA1KDM4E
SCHEMBL11160969 0.77 TDP1 (0.48) MAPTALDH1A1CHRNB2CHRNA4
SCHEMBL27848652 0.76 PTGDR2 (0.43) ALDH1A1CHRNB2CHRNA4KDM4EKMT2A
SCHEMBL10899805 0.75 NUDT1 (0.54) MAPTALDH1A1ESR2ESR1HSP90AB1
SCHEMBL17699117 0.75 CHRNB2 (0.55) MAPTALDH1A1ESR2ESR1HSP90AB1
SCHEMBL6807066 0.75 PTGDR2 (0.49) CHRNB2CHRNA4MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1165513-A1 INDOLINONE COMPOUNDS AS KINASE INHIBITORS Sugen, Inc. (US) 2002-01-02 EP disclosed
WO-2000056709-A1 INDOLINONE COMPOUNDS AS KINASE INHIBITORS SUGEN, INC. (US) 2000-09-28 WO disclosed