Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.48 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.40 |
| ▸ | WDR5 | P61964 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7461647 | 0.89 | EGFR (0.48) | ALDH1A1EGFRMAPTHTR6PDE5A | |
| SCHEMBL7466276 | 0.89 | MAPK1 (0.56) | ALDH1A1HPGDHTTEGFRRXFP1 | |
| SCHEMBL7470191 | 0.89 | EGFR (0.48) | EGFRMAPTHTR6PDE5AWDR5 | |
| SCHEMBL7468826 | 0.87 | EGFR (0.56) | ALDH1A1HPGDHTTEGFRMAPT | |
| SCHEMBL7466331 | 0.85 | ALDH1A1 (0.48) | ALDH1A1HTTEGFRMAPTHTR6 | |
| SCHEMBL7469783 | 0.85 | ALDH1A1 (0.48) | ALDH1A1HPGDEGFRMAPTHTR6 | |
| SCHEMBL7470206 | 0.84 | EGFR (0.52) | ALDH1A1HPGDHTTEGFRMAPT | |
| SCHEMBL7468165 | 0.84 | EGFR (0.41) | ALDH1A1HTTEGFRPOLBMAPT | |
| SCHEMBL7469830 | 0.83 | HTR6 (0.44) | ALDH1A1EGFRPOLBMAPTHTR6 | |
| SCHEMBL7475684 | 0.83 | EGFR (0.53) | ALDH1A1HTTEGFRMAPTHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1229025-A1 | NOVEL QUINAZOLINE DERIVATIVES | Japan Energy Corporation (JP) | 2002-08-07 | — | — | EP | disclosed |