Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18663736 | 0.86 | RAB9A (0.54) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL7087158 | 0.84 | CTSD (0.51) | NPC1RAB9ASMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL6095123 | 0.83 | KMT2A (0.56) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL11167218 | 0.81 | KMT2A (0.55) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL344646 | 0.81 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL4590566 | 0.81 | LMNA (0.52) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL6263649 | 0.79 | KMT2A (0.59) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL3762150 | 0.78 | RAB9A (0.55) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL341046 | 0.77 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL152563 | 0.77 | MAPT (0.59) | NPC1RAB9ASMN1; SMN2TP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1204657-A1 | PIPERIDINE AND PYRROLIDINE DERIVATIVES DISPLAYING NEURONAL ACTIVITY | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-05-15 | — | — | EP | disclosed |
| WO-2001012622-A1 | PIPERIDINE AND PYRROLIDINE DERIVATIVES DISPLAYING NEURONAL ACTIVITY | SCHERING AKTIENGESELLSCHAFT (DE) | 2001-02-22 | — | — | WO | disclosed |